Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans

Target of rapamycin complex 1 (TORC1) and AMP-activated protein kinase (AMPK) antagonistically modulate metabolism and aging. However, how they coordinate to determine longevity and if they act via separable mechanisms is unclear. Here, we show that neuronal AMPK is essential for lifespan extension...

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Principais autores:	Yue Zhang, Anne Lanjuin, Suvagata Roy Chowdhury, Meeta Mistry, Carlos G Silva-García, Heather J Weir, Chia-Lin Lee, Caroline C Escoubas, Emina Tabakovic, William B Mair
Format:	Artigo
Jezik:	Inglês
Izdano:	eLife Sciences Publications Ltd 2019-08-01
Serija:	eLife
Teme:	aging TORC1 AMPK mitochondria
Online dostop:	https://elifesciences.org/articles/49158
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