PRV UL13 inhibits cGAS–STING-mediated IFN-β production by phosphorylating IRF3

Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) is an intracellular sensor of cytoplasmic viral DNA created during virus infection, which subsequently activates the stimulator of interferon gene (STING)-dependent type I interferon response to eliminate pathogens. In contrast, viruses have developed...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Zongyi Bo, Yurun Miao, Rui Xi, Qiuping Zhong, Chenyi Bao, Huan Chen, Liumei Sun, Yingjuan Qian, Yong-Sam Jung, Jianjun Dai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2020-09-01
Edice:	Veterinary Research
Témata:	pseudorabies virus cGAS–STING UL13 serine/threonine kinase protein IRF3
On-line přístup:	http://link.springer.com/article/10.1186/s13567-020-00843-4
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!