Feasibility of stereotactic radiotherapy with pembrolizumab in patients with deficient mismatch repair/microsatellite unstable metastatic colorectal cancer

Background: Patients with metastatic colorectal cancer (mCRC) carrying a deficit in the mismatch repair system/microsatellite instability (dMMR/MSI) show great responses to immune checkpoint inhibitors. However, 30% of patients with dMMR/MSI are primarily immunoresistant, and another 30% develop sec...

Description complète

Détails bibliographiques

Auteurs principaux:	A. Gandini, V. Martelli, L. Belgioia, S. Puglisi, M. Cremante, V. Murianni, A. Damassi, C. Pirrone, F. Catalano, M. Grassi, L. Trevisan, S. Vagge, V. Andretta, S. Mammoliti, D. Comandini, G. Fornarini, A. Pessino, A. Pastorino, S. Sciallero, A. Puccini, A.F. Sobrero
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2024-09-01
Collection:	ESMO Gastrointestinal Oncology
Sujets:	immunotherapy radiotherapy colorectal cancer immunomodulation abscopal effect combined modality therapy
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S294981982400030X
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!