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Co-infusion of mesenchymal stromal cells to prevent GVHD after allogeneic hematopoietic cell transplantation from HLA-mismatched unrelated donors after reduced-intensity conditioning: a double-blind randomized study and literature review

Abstract Background Mesenchymal stromal cells (MSC) have immunomodulatory and hematopoiesis-supporting properties that could potentially benefit hematopoietic stem cell (HSC) engraftment and decrease the incidence and/or severity of graft-versus-host disease (GVHD). Methods Based on our previous pil...

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Principais autores: Gérôme Lombardo, Chantal Lechanteur, Alexandra Briquet, Laurence Seidel, Evelyne Willems, Sophie Servais, Etienne Baudoux, Tessa Kerre, Pierre Zachee, Julie Herman, Audrey Janssen, Joséphine Muller, Frédéric Baron, Yves Beguin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-12-01
coleção:Stem Cell Research & Therapy
Assuntos:
Allogeneic hematopoietic cell transplantation
Mesenchymal stromal cells
GVHD
Prevention
HLA mismatch
Acesso em linha:https://doi.org/10.1186/s13287-024-04064-w
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