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The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy

Abstract Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcino...

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Wedi'i Gadw mewn:
Prif Awduron: Jimin Yuan, Xiaoduo Dong, Jiajun Yap, Jiancheng Hu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2020-08-01
Cyfres:Journal of Hematology & Oncology
Pynciau:
Ras/RAF/MEK/ERK signaling
AMPK signaling
Interplay
Tumorigenesis
Cellular metabolism
RAF/MEK/ERK inhibitors
Mynediad Ar-lein:http://link.springer.com/article/10.1186/s13045-020-00949-4
Tagiau: Ychwanegu Tag
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