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Induced pluripotent stem cell-derived brain organoids as potential human model system for chemotherapy induced CNS toxicity

Neurotoxic phenomena are among the most common side effects of cytotoxic agents. The development of chemotherapy-induced polyneuropathy (CIPN) is a well-recognized adverse reaction in the peripheral nervous system, while changes of cognitive functions (post-chemotherapy cognitive impairment (PCCI))...

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Principais autores: Sophie Scholz, Karyn Lewis, Frederik Saulich, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-09-01
coleção:Frontiers in Molecular Biosciences
Assuntos:
brain organoids
iPSC (induced pluripotent stem cell)
chemotherapy
paclitaxel
neurotoxicity
apoptosis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmolb.2022.1006497/full
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