Directed evolution of phosphite dehydrogenase to cycle noncanonical redox cofactors via universal growth selection platform
Engineering enzymes to utilize the noncanonical redox cofactors such as nicotinamide mononucleotide (NMN + ) is challenging. Here, the authors report a growth-based selection platform for NMN + -reducing enzyme engineering and show its application in developing a phosphite dehydrogenase with improve...
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| Principais autores: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2022-08-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-022-32727-w |
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