Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4

Sterol homeostasis is essential for the function of cellular membranes and requires feedback inhibition of HMGR, a rate-limiting enzyme of the mevalonate pathway. As HMGR acts at the beginning of the pathway, its regulation affects the synthesis of sterols and of other essential mevalonate-derived m...

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Autors principals:	Ombretta Foresti, Annamaria Ruggiano, Hans K Hannibal-Bach, Christer S Ejsing, Pedro Carvalho
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2013-07-01
Col·lecció:	eLife
Matèries:	endoplasmic reticulum ERAD sterol homeostasis squalene monooxygenase DOA10 TEB4
Accés en línia:	https://elifesciences.org/articles/00953
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