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Astrocytic Slc4a4 regulates blood-brain barrier integrity in healthy and stroke brains via a CCL2-CCR2 pathway and NO dysregulation

Summary: Astrocytes play vital roles in blood-brain barrier (BBB) maintenance, yet how they support BBB integrity under normal or pathological conditions remains poorly defined. Recent evidence suggests that ion homeostasis is a cellular mechanism important for BBB integrity. In the current study, w...

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Huvudupphov: Qi Ye, Juyeon Jo, Chih-Yen Wang, Heavin Oh, Jiangshan Zhan, Tiffany J. Choy, Kyoung In Kim, Angelo D’Alessandro, Yana K. Reshetnyak, Sung Yun Jung, Zheng Chen, Sean P. Marrelli, Hyun Kyoung Lee
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2024-05-01
Serie:Cell Reports
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Länkar:http://www.sciencedirect.com/science/article/pii/S2211124724005217
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