Increased risk of hyperthyroidism induced by immune checkpoint inhibitors in patients with existing or prior Graves’ disease: a nested prospective cohort study with propensity score matching

BackgroundThyroid dysfunction induced by immune checkpoint inhibitors (ICIs) commonly manifests as destructive thyroiditis and hypothyroidism, while hyperthyroidism (Graves’ disease) is rare. However, the clinical characteristics of thyroid dysfunction in patients with existing or prior Graves’ dise...

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Autori principali:	Koji Suzuki, Tomoko Kobayashi, Tetsushi Izuchi, Takanori Murase, Masahiko Ando, Tomoko Handa, Takeshi Onoue, Takashi Miyata, Mariko Sugiyama, Daisuke Hagiwara, Hidetaka Suga, Ryoichi Banno, Hiroshi Arima, Shintaro Iwama
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2025-12-01
Serie:	Frontiers in Endocrinology
Soggetti:	hyperthyroidism PD-1 inhibitor CTLA-4 inhibitor Graves’ recurrence
Accesso online:	https://www.frontiersin.org/articles/10.3389/fendo.2025.1701500/full
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