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UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract

Abstract Background Urinary tract catheters, including Double-J or ureteral stents, are prone to bacterial colonization forming biofilms and leading to asymptomatic bacteriuria. In the context of asymptomatic bacteriuria, endourological procedures causing mucosa-inducing lesions can lead to severe i...

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Principais autores: Kevin Stritt, Beat Roth, Audrey Masnada, Felix Hammann, Damien Jacot, Sonia Domingos-Pereira, François Crettenand, Perrine Bohner, Isabelle Sommer, Emilien Bréat, Julien Sauser, Laurent Derré, Manuel Haschke, James J. Collins, John McKinney, Sylvain Meylan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-10-01
Serier:Trials
Fag:
Antimicrobial prophylaxis
Endourological procedures
Postoperative infections
Biofilm
Potentiated aminoglycosides
Online adgang:https://doi.org/10.1186/s13063-024-08526-7
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