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9-aminominocycline potentiates the efficacy of EIDD-1931 and PF-332 by targeting the papain like protease enzyme of SARS-CoV-2

Abstract The 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), and RNA-dependent RNA polymerase (RdRp) are key enzymes in SARS-CoV-2 replication and serve as critical targets for an antiviral drug. Currently, Paxlovid® and Lagevrio™ specifically target 3CLpro and RdRp, respectivel...

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Principais autores: Kabita Pandey, Devin Shane M. Lewis, Kyeongin Heo, Arpan Acharya, Travis Fields, Kritika Gowda, George Dean, Srujana Rayalam, Siddappa N. Byrareddy, Vicky Mody, Shashidharamurthy Taval
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-02-01
Serier:Scientific Reports
Fag:
SARS-CoV-2
Replication
PLpro inhibitor
Enzyme kinetics
Online adgang:https://doi.org/10.1038/s41598-025-89717-3
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