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Engineering Peptide Inhibitors of the HFE–Transferrin Receptor 1 Complex

The protein HFE (homeostatic iron regulator) is a key regulator of iron metabolism, and mutations in HFE underlie the most frequent form of hereditary haemochromatosis (HH-type I). Studies have shown that HFE interacts with transferrin receptor 1 (TFR1), a homodimeric type II transmembrane glycoprot...

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Principais autores: Daniela Goncalves Monteiro, Gautam Rishi, Declan M. Gorman, Guillaume Burnet, Randy Aliyanto, K. Johan Rosengren, David M. Frazer, V. Nathan Subramaniam, Richard J. Clark
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-10-01
Serier:Molecules
Fag:
hepcidin
stapling
HFE
TFR1
Online adgang:https://www.mdpi.com/1420-3049/27/19/6581
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