Spatiotemporal analysis of SARS-CoV-2 infection reveals an expansive wave of monocyte-derived macrophages associated with vascular damage and virus clearance in hamster lungs

ABSTRACT Lung immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for the ability to deal with infection. Using light sheet fluorescence microscopy of hamster lung slices in combination with virological, immunohistochemical, and RNA sequencing analyses, we sho...

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Hlavní autoři:	Ola Bagato, Anne Balkema-Buschmann, Daniel Todt, Saskia Weber, André Gömer, Bingqian Qu, Csaba Miskey, Zoltan Ivics, Thomas C. Mettenleiter, Stefan Finke, Richard J. P. Brown, Angele Breithaupt, Dmitry S. Ushakov
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology 2024-01-01
Edice:	Microbiology Spectrum
Témata:	SARS-CoV-2 innate immunity light sheet fluorescence microscopy transcriptomics Golden Syrian hamster COVID-19
On-line přístup:	https://journals.asm.org/doi/10.1128/spectrum.02469-23
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