IL-21 Is an Accomplice of PD-L1 in the Induction of PD-1-Dependent Treg Generation in Head and Neck Cancer

Regulatory T cells (Tregs) are immunosuppressive cells involved in antitumor immunity. However, the regulation of Treg generation by inflammation in the tumor microenvironment has not been carefully investigated. Here, we demonstrated that IL-21-polarized inflammation was enriched in the tumor micro...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yi Zhao, Zhiyu Zhang, Wenbin Lei, Yi Wei, Renqiang Ma, Yihui Wen, Fanqin Wei, Jun Fan, Yang Xu, Lin Chen, Kexing Lyu, Hanqing Lin, Weiping Wen, Wei Sun
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2021-05-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	interleukin-21 regulatory T cells programmed death-ligand 1 tumor microenvironment head and neck squamous cell carcinoma
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fonc.2021.648293/full
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