Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

Abstract Excessive immune activation and immunosuppression are opposing factors that contribute to the dysregulated innate and adaptive immune responses seen in severe inflammation and sepsis. Here, a novel analog of the histone deacetylase inhibitor (HDACi), suberoylanilide hydroxamic acid (SAHA‐OH...

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Príomhchruthaitheoirí:	Nhu Truong, Andrea L. Cottingham, Shruti Dharmaraj, Jacob R. Shaw, Jackline Joy Martin Lasola, Christopher C. Goodis, Steven Fletcher, Ryan M. Pearson
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	Wiley 2024-01-01
Sraith:	Bioengineering & Translational Medicine
Ábhair:	drug delivery histone deacetylase inhibitor inflammation lipopolysaccharide‐induced endotoxemia nanoparticle sepsis
Rochtain ar líne:	https://doi.org/10.1002/btm2.10611
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Multimodal nanoparticle‐containing modified suberoylanilide hydroxamic acid polymer conjugates to mitigate immune dysfunction in severe inflammation

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