In-depth comparison of Anc80L65 and AAV9 retinal targeting and characterization of cross-reactivity to multiple AAV serotypes in humans

Anc80L65 is a synthetic, ancestral adeno-associated virus that has high tropism toward retinal photoreceptors after subretinal injection in mice and non-human primates. We characterized, for the first time, the post-intravitreal cell-specific transduction profile of Anc80L65 compared with AAV9. Here...

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Egile Nagusiak:	Maura K. Schwartz, Shibi Likhite, Tatyana A. Vetter, Megan C. Baird, Vicki McGovern, Andrea Sierra Delgado, Tom Mendel, Arthur Burghes, Kathrin C. Meyer
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2023-09-01
Saila:	Molecular Therapy: Methods & Clinical Development
Gaiak:	AAV intravitreal subretinal retina transduction immunity
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2329050123000785
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