The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition
MYC performs a dual role in DNA Damage Response (DDR), promoting genomic instability through replication stress, R-loop formation, and topoisomerase-mediated damage, while simultaneously activating DNA repair pathways to maintain cell survival. This review provides a comprehensive analysis of how MY...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2026-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Assuntos: | |
| Acceso en liña: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1726515/full |
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