Inhibition of the mRNA-Binding Protein IGF2BP1 Suppresses Proliferation and Sensitizes Neuroblastoma Cells to Chemotherapeutic Agents

Gain at chromosome 17q21 in neuroblastoma is associated with a poor prognosis, independent of MYCN amplification status. Several potential proto-oncogenes have been identified in this region, one of them—insulin-like growth-factor-2 mRNA binding protein (IGF2BP1)—is expressed at high levels in stage...

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Principais autores:	Jason M. Biegel, Mayura Dhamdhere, Shuang Gao, Chethana P. Gowda, Yuka Imamura Kawasawa, Vladimir S. Spiegelman
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Oncology
Assuntos:	IGF2BP1 neuroblastoma RBP sensitivity to chemotherapeutics cell proliferation CDK inhibitor
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fonc.2021.608816/full
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