Structural and biochemical differences between non-catalytic and catalytic antibodies

A conventional antibody can be converted into its catalytic counterparts by deleting Pro95 in the CDR-3 of human and mice antibody light chains, as previously reported. T99wt is a naturally occurring human antibody light chain that we transformed into its catalytic antibody using Pro95 deletion. In...

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Detalles Bibliográficos

Principais autores:	Taizo Uda, Ryuichi Kato, Yasuteru Shigeta, Shun Hirota, Jun Kobayashi, Hisashi Yoshida, Masato Tsuyuguchi, Kowit Hengphasatporn, Moe Tsujita, Hiroaki Taguchi, Emi Hifumi
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2025-12-01
Series:	mAbs
Assuntos:	Catalytic antibody pro95 residue deletion amyloid-beta tau-protein X-ray crystallography molecular dynamics
Acceso en liña:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2503978
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