Fed-Batch Production of Saccharomyces cerevisiae L-Asparaginase II by Recombinant Pichia pastoris MUTs Strain

L-Asparaginase (ASNase) is used in the treatment of acute lymphoblastic leukemia, being produced and commercialized only from bacterial sources. Alternative Saccharomyces cerevisiae ASNase II coded by the ASP3 gene was biosynthesized by recombinant Pichia pastoris MUTs under the control of the AOX1...

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Detalhes bibliográficos

Principais autores:	David Rodrigues, Omar Pillaca-Pullo, Karin Torres-Obreque, Juan Flores-Santos, Ignacio Sánchez-Moguel, Marcela V. Pimenta, Tajindar Basi, Attilio Converti, André M. Lopes, Gisele Monteiro, Luís P. Fonseca, Adalberto Jr. Pessoa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-02-01
coleção:	Frontiers in Bioengineering and Biotechnology
Assuntos:	L-Asparaginase Pichia pastoris defined medium fed-batch fermentation high cell density culture heterologous protein production
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fbioe.2019.00016/full
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