Rottlerin triggers dual degradation of SLC7A11 and GPX4 to drive ferroptosis and chemosensitization in hepatocellular carcinoma

Abstract Natural products have emerged as promising therapeutic agents for targeting redox vulnerabilities in cancer. Rottlerin, a bioactive polyphenol derived from Mallotus philippinensis, exhibits broad anticancer properties through autophagy and apoptosis induction. However, its capacity to modul...

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מידע ביבליוגרפי

Principais autores:	Hongliang Luo, Xiaorui Jin, Chengchang Gao, Qinqin Deng, Linfen Han, Fumin Hu, Rui Tong, Donglin Li, Haoying Yang, Xueli Bian
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Nature Publishing Group 2026-01-01
סדרה:	Cell Death Discovery
גישה מקוונת:	https://doi.org/10.1038/s41420-026-02942-1
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!