The role of macrophages in the mitigation by decitabine of acute allograft rejection
IntroductionWe have recently shown that the DNA hypomethylating agent decitabine (DAC) rescues lung allografts from acute rejection. This involves a mechanism that is dependent on host CD4+ FoxP3+ T cells for maximal benefit. DAC treatment also reduces host T-cell IFN-γ production. We therefore hypo...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Frontiers Media S.A.
2025-12-01
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| Series: | Frontiers in Transplantation |
| Assuntos: | |
| Acceso en liña: | https://www.frontiersin.org/articles/10.3389/frtra.2025.1723396/full |
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