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In Silico Design and Verification of LAMP-BDNF Chimeric Protein for Presentation of BDNF on the Surface of Exosomes for Drug Delivery Through Blood-Brain Barrier

Background and purpose: The mature form of brain-derived neurotrophic factor (BDNF) binds to BDNF/NT-3 growth factors receptor (Trk-B). This binding leads to activation of Ras–MAPK pathway which is integrated with cell growth and proliferation. The BDNF deficiency is correlated with various diseases...

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Principais autores: Saeed Khalili, Seyedeh Farzaneh Mahdavian, Niloufar Ahmadifard, Reza Valadan, Naghi Shahabi Majd, Hosein Ranjbaran, Mohammad Reza Mahdavi, Atena Sharif Razavi, Shabanali Khodashenas
Formato: Artigo
Idioma:Inglês
Publicado em: Mazandaran University of Medical Sciences 2022-12-01
coleção:Journal of Mazandaran University of Medical Sciences
Assuntos:
exosomes
bdnf
trk-b
lamp2
drug delivery
Acesso em linha:http://jmums.mazums.ac.ir/article-1-17695-en.html
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