CAR T cells derived from a novel, high-affinity anti-CLL-1 monoclonal antibody exhibit a significant anti-AML effect

Abstract CAR T cells targeting CLL-1 have shown antileukemia efficacy in patients with acute myeloid leukemia (AML). However, CLL-1low/− AML cells are present in some patients, suggesting that the development of CAR T cells with high sensitivity is necessary to eradicate all AML clones in these pati...

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Hlavní autoři:	Shuhei Kida, Makiko Suga, Yuta Yamaguchi, Shunya Ikeda, Yosuke Kogue, Ryuhei Kawamoto, Kumi Shibata, Kazuhito Tsutsumi, Hiraku Murakami, Emiko Mizuta, Yo Mizutani, Naoki Hosen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer 2026-03-01
Edice:	Cancer Immunology, Immunotherapy
Témata:	CAR T cells AML CLL-1 Revumenib Menin inhibitor
On-line přístup:	https://doi.org/10.1007/s00262-026-04342-x
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