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Extracellular Vesicles-mediated recombinant IL-10 protects against ascending infection-associated preterm birth by reducing fetal inflammatory response

BackgroundFetal inflammatory response mediated by the influx of immune cells and activation of pro-inflammatory transcription factor NF-κB in feto-maternal uterine tissues is the major determinant of infection-associated preterm birth (PTB, live births < 37 weeks of gestation).ObjectiveTo reduce...

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Principais autores: Ananth Kumar Kammala, Angela Mosebarger, Enkhtuya Radnaa, Emma Rowlinson, Natasha Vora, Stephen J. Fortunato, Surendra Sharma, Melody Safarzadeh, Ramkumar Menon
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-08-01
coleção:Frontiers in Immunology
Assuntos:
pregnancy
extracellular vesicles
ascending infection
fetal membranes
anti-inflammatory
antibiotics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1196453/full
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