Bacillus subtilis encodes a discrete flap endonuclease that cleaves RNA-DNA hybrids.
The current model for Okazaki fragment maturation in bacteria invokes RNA cleavage by RNase H, followed by strand displacement synthesis and 5' RNA flap removal by DNA polymerase I (Pol I). RNA removal by Pol I is thought to occur through the 5'-3' flap endo/exonuclease (FEN) domain, located in the...
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| Үндсэн зохиолчид: | , |
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| Формат: | Artigo |
| Хэл сонгох: | Inglês |
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Public Library of Science (PLoS)
2023-05-01
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| Цуврал: | PLoS Genetics |
| Онлайн хандалт: | https://doi.org/10.1371/journal.pgen.1010585 |
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