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IMT504 accelerates post-hepatectomy liver regeneration in mice with involvement of GLAST + Wnt1 + bone marrow stromal progenitors

Abstract The immunomodulatory oligodeoxynucleotide (ODN) IMT504 exhibits antifibrotic and pro-regenerative properties in the context of liver fibrosis. It also enhances the contribution of GLAST+ Wnt1+ bone marrow stromal progenitors (BMSPs) to liver regeneration in a mouse model of chronic liver di...

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Principais autores: Maximiliano Borda, Lucía Cafaro, Romina Sierra, Mercedes Díaz Pedraza, Camila Becerra, Agustina Ábalo, María José Karolewski, María José Cantero, Máximo Schiavone, Guillermo D. Mazzolini, Alejandro Montaner, Esteban J. Fiore, Jorge B. Aquino
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-10-01
Serier:Scientific Reports
Fag:
Developmental plasticity
Bone marrow stromal progenitors
Proliferation
Differentiation
Hepatocytes
Endothelial cells
Online adgang:https://doi.org/10.1038/s41598-025-22097-w
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