Neoantigens and shared MICB α3 antigen dual-targeted vaccine generates potent antitumor immunity

Abstract Immune suppression is one of the primary obstacles in neoantigen immunotherapy because tumors can rapidly adapt by reducing MHC-I expression or antigen presentation. Here, we developed a novel immunotherapy strategy that combined vaccination of neoantigens with MICB α3 antigen, by using bac...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Ruijing Tang, Honghao Ye, Geng Chen, Xiuqing Dong, Zhenli Li, Fangzhou Lin, Tingfeng Huang, Liman Qiu, Gengping Lin, Ming Wu, Haijun Yu, Jianhua Zou, Xiaolong Liu, Zhixiong Cai
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2026-04-01
Schriftenreihe:	EMBO Molecular Medicine
Online-Zugang:	https://doi.org/10.1038/s44321-026-00424-6
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