Synaptic proteins promote calcium-triggered fast transition from point contact to full fusion

The molecular underpinnings of synaptic vesicle fusion for fast neurotransmitter release are still unclear. Here, we used a single vesicle–vesicle system with reconstituted SNARE and synaptotagmin-1 proteoliposomes to decipher the temporal sequence of membrane states upon Ca2+-injection at 250–500 μ...

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Bibliografiske detaljer

Principais autores:	Jiajie Diao, Patricia Grob, Daniel J Cipriano, Minjoung Kyoung, Yunxiang Zhang, Sachi Shah, Amie Nguyen, Mark Padolina, Ankita Srivastava, Marija Vrljic, Ankita Shah, Eva Nogales, Steven Chu, Axel T Brunger
Format:	Artigo
Sprog:	Inglês
Udgivet:	eLife Sciences Publications Ltd 2012-12-01
Serier:	eLife
Fag:	neurotransmitter release synaptic vesicle fusion SNARE synaptotagmin complexin
Online adgang:	https://elifesciences.org/articles/00109
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