Interferon-γ induces interleukin-6 production by neutrophils via the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway

Abstract Objective Interferon-gamma (IFN-γ) is overexpressed in rheumatoid synovium and thought to be involved in the pathogenesis of rheumatoid arthritis (RA). In this study, we examined our hypothesis that IFN-γ activates innate immune cells and upregulates inflammatory cytokines. Peripheral blood...

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Autors principals:	Shuhei Yoshida, Shunya Yamada, Kohei Yokose, Haruki Matsumoto, Yuya Fujita, Tomoyuki Asano, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Makiko Yoshiro-Furuya, Hiroshi Watanabe, Kiyoshi Migita
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2021-12-01
Col·lecció:	BMC Research Notes
Matèries:	Cytokines Interferon-γ Interleukin-6 Janus kinase (JAK) Neutrophils Rheumatoid arthritis
Accés en línia:	https://doi.org/10.1186/s13104-021-05860-w
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