Quantitative analysis of α-L-iduronidase expression in immunocompetent mice treated with the Sleeping Beauty transposon system.

The Sleeping Beauty transposon system, a non-viral, integrating vector that can deliver the alpha-L-iduronidase-encoding gene, is efficient in correcting mucopolysaccharidosis type I in NOD/SCID mice. However, in previous studies we failed to attain reliable long-term alpha-L-iduronidase expression...

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Hlavní autoři:	Elena L Aronovich, Bryan C Hall, Jason B Bell, R Scott McIvor, Perry B Hackett
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2013-01-01
Edice:	PLoS ONE
On-line přístup:	http://europepmc.org/articles/PMC3804460?pdf=render
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