Glypican 3-targeted chimeric antigen receptor T cells secreting TROP2-directed bispecific T cell engagers exhibit potent efficacy against lung squamous cell carcinoma

BackgroundChimeric antigen receptor T cell (CAR-T) therapy faces multiple challenges in solid tumors, especially the heterogeneity of tumor antigens. Glypican-3 (GPC3) and trophoblast cell-surface antigen 2 (TROP2) are highly expressed antigens in lung squamous cell carcinoma (LUSC) for development...

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Autori principali:	Lianjie Ruan, Liming Lin, Dekai Lin, Haiqing Zhang, Suiyan Weng, Mengqing Lin
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-01-01
Serie:	Frontiers in Immunology
Soggetti:	BiTE CAR-T GPC3 lung squamous cell carcinoma TROP2
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1709316/full
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