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Phenotypic characterization of spatial immune infiltration niches in non-small cell lung cancer

The immune microenvironment of non-small cell lung cancer (NSCLC) is heterogeneous, which impedes the prediction of response to immune checkpoint inhibitors. We have mapped the expression of 49 proteins to spatial immune niches in 33 NSCLC tumors and report key differences in phenotype and function...

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Principais autores: Anna Sandström Gerdtsson, Mattis Knulst, Johan Botling, Artur Mezheyeuski, Patrick Micke, Sara Ek
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2023-12-01
coleção:OncoImmunology
Assuntos:
NSCLC
immune infiltration
tertiary lymphoid structures
tumor-infiltrating leukocytes
spatial omics
Acesso em linha:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2206725
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