Unraveling the unphosphorylated STAT3–unphosphorylated NF-κB pathway in loss of function STAT3 Hyper IgE syndrome

BackgroundPatients with loss of function signal transducer and activator of transcription 3-related Hyper IgE Syndrome (LOF STAT3 HIES) present with recurrent staphylococcal skin and pulmonary infections along with the elevated serum IgE levels, eczematous rashes, and skeletal and facial abnormaliti...

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Prif Awduron:	Adil Karim, Rashi Garg, Biman Saikia, Abha Tiwari, Smrity Sahu, Mehak Malhotra, Ranjana W. Minz, Amit Rawat, Surjit Singh, Deepti Suri
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2024-08-01
Cyfres:	Frontiers in Immunology
Pynciau:	inborn error of immunity (IEI) primary immunodeficencies (PID) Hyper IgE syndrome (HIES) signal transducer and activator of transcription 3 (STAT3) Regulated upon Activation normal T-cell expressed and secreted chemokines (RANTES)
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1332817/full
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