A rare loss-of-function genetic mutation suggest a role of dermcidin deficiency in hidradenitis suppurativa pathogenesis

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a multifactorial aetiology that involves a strict interplay between genetic factors, immune dysregulation and lifestyle. Familial forms represent around 40% of total HS cases and show an autosomal dominant mode of inheritance...

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Principais autores:	Paola Maura Tricarico, Rossella Gratton, Carlos André dos Santos-Silva, Ronald Rodrigues de Moura, Blendi Ura, Eduardo Sommella, Pietro Campiglia, Cecilia Del Vecchio, Chiara Moltrasio, Irene Berti, Adamo Pio D’Adamo, Ahmed M. A. Elsherbini, Lena Staudenmaier, Karin Chersi, Michele Boniotto, Bernhard Krismer, Birgit Schittek, Sergio Crovella
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Immunology
Assuntos:	hidradenitis suppurativa dermcidin genetics antimicrobial peptides bacteria
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1060547/full
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