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The supporting role of Schwann cells in perineural invasion of pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with tumor cells readily disseminating to other organs through the bloodstream, lymphatic system, and nervous system, thereby impacting patients’ survival rates. PDAC is often associated with perineural invasion (PNI), which not...

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Autori principali: Yun He, Zheng Chen, Liu Yang, Shuanying Qiao, Zonghua Su, Feng Ding, Fadian Ding, Fuli Xin, Siyu Xiang, Aiping Lyu, Fangfei Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-06-01
Serie:Frontiers in Pharmacology
Soggetti:
pancreatic ductal adenocarcinoma
perineural invasion
Schwann cells
tumor microenvironment
peripheral nervous system
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2025.1540027/full
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