Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

Abstract DDX3X is a DEAD-box RNA helicase that has been implicated in multiple aspects of RNA metabolism including translation initiation and the assembly of stress granules (SGs). Recent genomic studies have reported recurrent DDX3X mutations in numerous tumors including medulloblastoma (MB), but t...

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Auteurs principaux:	Yasmine A. Valentin-Vega, Yong-Dong Wang, Matthew Parker, Deanna M. Patmore, Anderson Kanagaraj, Jennifer Moore, Michael Rusch, David Finkelstein, David W. Ellison, Richard J. Gilbertson, Jinghui Zhang, Hong Joo Kim, J. Paul Taylor
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2016-05-01
Collection:	Scientific Reports
Accès en ligne:	https://doi.org/10.1038/srep25996
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