Polymicrobial Sepsis Chronic Immunoparalysis Is Defined by Diminished Ag-Specific T Cell-Dependent B Cell Responses

Immunosuppression is one hallmark of sepsis, decreasing the host response to the primary septic pathogens and/or secondary nosocomial infections. CD4 T cells and B cells are among the array of immune cells that experience reductions in number and function during sepsis. “Help” from follicular helper...

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Prif Awduron:	Frances V. Sjaastad, Stephanie A. Condotta, Jessica A. Kotov, Kathryn A. Pape, Cody Dail, Derek B. Danahy, Tamara A. Kucaba, Lorraine T. Tygrett, Katherine A. Murphy, Javier Cabrera-Perez, Thomas J. Waldschmidt, Vladimir P. Badovinac, Thomas S. Griffith
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2018-10-01
Cyfres:	Frontiers in Immunology
Pynciau:	sepsis B cells immune suppression antibody CD4 T cells
Mynediad Ar-lein:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02532/full
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