Manufacturing and preclinical toxicity of GLP grade gene deleted attenuated Leishmania donovani parasite vaccine

Abstract Centrin1 gene deleted Leishmania donovani parasite (LdCen1 −/− ) was developed and extensively tested experimentally as an intracellular stage-specific attenuated and immunoprotective live parasite vaccine candidate ex vivo using human PBMCs and in vivo in animals. Here we report manufactur...

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Detalhes bibliográficos

Principais autores:	Kumar Avishek, Mirza A. Beg, Kavita Vats, Avinash Kumar Singh, Ranadhir Dey, Kamaleshwar P. Singh, Rajesh Kumar Singh, Sreenivas Gannavaram, V. Ramesh, Mohmad Sadik A. Mulla, Upendra Bhatnagar, Sanjay Singh, Hira L. Nakhasi, Poonam Salotra, Angamuthu Selvapandiyan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2024-06-01
coleção:	Scientific Reports
Assuntos:	Leishmania donovani Visceral leishmaniasis Vaccine candidate Live attenuated Preclinical Toxicity study
Acesso em linha:	https://doi.org/10.1038/s41598-024-64592-6
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