Modeling Patient-Specific Muscular Dystrophy Phenotypes and Therapeutic Responses in Reprogrammed Myotubes Engineered on Micromolded Gelatin Hydrogels

In vitro models of patient-derived muscle allow for more efficient development of genetic medicines for the muscular dystrophies, which often present mutation-specific pathologies. One popular strategy to generate patient-specific myotubes involves reprogramming dermal fibroblasts to a muscle lineag...

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Hlavní autoři:	Florian Barthélémy, Jeffrey W. Santoso, Laura Rabichow, Rongcheng Jin, Isaiah Little, Stanley F. Nelson, Megan L. McCain, M. Carrie Miceli
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-04-01
Edice:	Frontiers in Cell and Developmental Biology
Témata:	DMD LGMD exon skipping hydrogels calpain 3 dystrophin
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcell.2022.830415/full
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