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Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-β1-Dependent Mechanism

Expression of the nerve growth factor NGF is increased in pulmonary hypertension (PH). We have here studied whether oxidative stress and inflammation, two pathological conditions associated with transforming growth factor-β1 (TGF-β1) in PH, may trigger NGF secretion by pulmonary arterial (PA) cells....

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Principais autores: Clément Bouchet, Guillaume Cardouat, Matthieu Douard, Florence Coste, Paul Robillard, Frédéric Delcambre, Thomas Ducret, Jean-François Quignard, Pierre Vacher, Isabelle Baudrimont, Roger Marthan, Patrick Berger, Christelle Guibert, Véronique Freund-Michel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-09-01
Colecção:Cells
Assuntos:
nerve growth factor NGF
pulmonary hypertension
oxidative stress
inflammation
transforming growth factor-β1 TGF-β1
pulmonary arterial smooth muscle cells
Acesso em linha:https://www.mdpi.com/2073-4409/11/18/2795
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