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Oridonin as a novel KDM5C inhibitor alleviates clonal hematopoiesis-induced cardiac aging via H3K4me3-dependent SASP suppression

TET2-mediated clonal hematopoiesis of indeterminate potential (CHIP) is a known cardiovascular risk factor, but its role in cardiac aging and potential for pharmacological intervention remain unclear. Herein, Mendelian randomization using large-scale genome-wide association studies (GWAS) data asses...

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Principais autores: Xingling Chen, Qiangqiang Zhao, Linhuang Chen, Shengrong Lin, Bin Mai, Xingling He, Xiaojiao Zhang, Jiahui Chen, Sijing Li, Ziru Li, Hua Zhang, Yuehui Zhou, Xiaofang Li, Huili Liao, Taochun Ye, Shuning Sun, Zhongqi Yang, Shihao Ni, Lu Lu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-05-01
Serier:Acta Pharmaceutica Sinica B
Fag:
Clonal hematopoiesis
TET2
Cardiac aging
Oridonin
KDM5C
SASP
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211383526001085
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