SUMO2-mediated SUMOylation of RRM1 regulates gemcitabine resistance in pancreatic ductal adenocarcinoma
MethodsA gemcitabine-resistant PANC1 cell line (PANC1_GR) was established, and the expression of SUMO1, SUMO2, and SUMO3 was assessed by Western blot. The SUMO-activating enzyme inhibitor ML-792 was used to suppress global SUMOylation, and cell proliferation and apoptosis were evaluated using the ce...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Editorial Office of China Oncology
2026-04-01
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| Series: | Zhongguo aizheng zazhi |
| Assuntos: | |
| Acceso en liña: | http://www.china-oncology.com/thesisDetails#10.19401/j.cnki.1007-3639.2026.04.002 |
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