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Hypoxic regulation of MYBL1, MEST, TCF3, TCF8, GTF2B, GTF2F2 and SNAI2 genes expression in U87 glioma cells upon IRE1 inhibition

We investigated the impact of IRE1/ERN1 (inositol requiring enzyme 1/endoplasmic reticulum to nucleus signaling 1) knockdown on hypoxic regulation of the expression of a subset of proliferation and migration-related genes in U87 glioma cells. It was shown that hypoxia leads to up-regulation of the e...

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Principais autores: O. H. Minchenko, D. O. Tsymbal, D. O. Minchenko, O. O. Kubaychuk
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry 2016-12-01
Serier:The Ukrainian Biochemical Journal
Fag:
glioma cells
GTF2B
GTF2F2
hypoxia
IRE1 inhibition
MEST
mRNA expression
MYBL1
SNAI2
TCF3
TCF8
Online adgang:http://ukrbiochemjournal.org/wp-content/uploads/2016/12/Minchenko_6_16.pdf
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