Neoadjuvant use of oncolytic herpes virus G47Δ prevents local recurrence after insufficient resection in tongue cancer models

A complete resection of tongue cancer is often difficult. We investigate the usefulness of administering G47Δ (teserpaturev), a triple-mutated oncolytic herpes simplex virus type 1, prior to resection. G47Δ exhibits good cytopathic effects and replication capabilities in all head and neck cancer cel...

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Detalhes bibliográficos

Principais autores:	Kosuke Inoue, Hirotaka Ito, Miwako Iwai, Minoru Tanaka, Yoshiyuki Mori, Tomoki Todo
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-09-01
Colecção:	Molecular Therapy: Oncolytics
Assuntos:	tongue cancer G47Δ oncolytic virus therapy immunotherapy neoadjuvant therapy local recurrence
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2372770523000487
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