Association of APOBEC mutagenesis with stromal and endothelial niche remodeling and PCDH9-linked signaling alterations in colorectal cancer

BackgroundAPOBEC cytidine deaminases generate characteristic TCW-context mutations that diversify cancer genomes, yet their functional impact on colorectal cancer (CRC) progression and the tumor microenvironment (TME) remains poorly defined.MethodsWe integrated whole-exome sequencing, bulk and singl...

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Principais autores:	Junting Chen, Jiaming Cao, Baosen Zhou, Lianshuang Zhao, Chang Zheng
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-07-01
Series:	Frontiers in Immunology
Assuntos:	APOBEC mutagenesis CRC endothelial lineage reprogramming PCDH9 tumor microenvironment remodeling
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1835351/full
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