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STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease

Alexander disease (AxD) is caused by mutations in the gene for glial fibrillary acidic protein (GFAP), an intermediate filament expressed by astrocytes in the central nervous system. AxD-associated mutations cause GFAP aggregation and astrogliosis, and GFAP is elevated with the astrocyte stress resp...

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Principais autores: Tracy L. Hagemann, Sierra Coyne, Alder Levin, Liqun Wang, Mel B. Feany, Albee Messing
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-03-01
Serier:Cells
Fag:
GFAP
STAT3
astrocyte
Alexander disease
Rosenthal fibers
reactive gliosis
Online adgang:https://www.mdpi.com/2073-4409/12/7/978
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