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Stability Study of mRNA-Lipid Nanoparticles Exposed to Various Conditions Based on the Evaluation between Physicochemical Properties and Their Relation with Protein Expression Ability

Lipid nanoparticles (LNPs) are currently in the spotlight as delivery systems for mRNA therapeutics and have been used in the Pfizer/BioNTech and Moderna COVID-19 vaccines. mRNA-LNP formulations have been indicated to require strict control, including maintenance at fairly low temperatures during th...

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Principais autores: Mariko Kamiya, Makoto Matsumoto, Kazuma Yamashita, Tatsunori Izumi, Maho Kawaguchi, Shusaku Mizukami, Masako Tsurumaru, Hidefumi Mukai, Shigeru Kawakami
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-10-01
Serier:Pharmaceutics
Fag:
mRNA-LNP
storage condition
stability
Online adgang:https://www.mdpi.com/1999-4923/14/11/2357
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