Alterations in T and B Cell Receptor Repertoires Patterns in Patients With IL10 Signaling Defects and History of Infantile-Onset IBD

Patients with loss-of-function mutations in IL10 or IL10 receptor (IL10R) genes develop severe, medical-refractory, infantile-onset inflammatory bowel disease (IBD). We have previously reported significant alterations in innate and adaptive immune responses in these patients. Next generation sequenc...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Lael Werner, Yu Nee Lee, Erez Rechavi, Atar Lev, Baruch Yerushalmi, Galina Ling, Neil Shah, Holm H. Uhlig, Batia Weiss, Raz Somech, Scott B. Snapper, Dror S. Shouval
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-02-01
coleção:	Frontiers in Immunology
Assuntos:	IBD VEOIBD NGS T cell receptor repertoire B cell receptor repertoire IL10
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00109/full
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!